Fantasy Football Alert: Brissett-Wilson Combo a Must-Target for Week 12

Last-minute pickups for Week 12: Target the Brissett-Wilson combo in Arizona

New York, November 27, 2025

Jacoby Brissett and Michael Wilson emerge as critical last-minute fantasy football options for Week 12 of the 2025 NFL season due to their recent performance surge and favorable matchup against the Jacksonville Jaguars’ struggling defense. Their pairing provides meaningful upside for fantasy managers targeting value plays in the coming games.

Jacoby Brissett has established himself as a reliable quarterback option, delivering nearly 21 fantasy points per game over recent weeks. Over the last two contests, Brissett has thrown for a league-high 769 yards, underscoring his role as the Arizona Cardinals’ primary offensive catalyst. This level of production places him among top-tier streaming choices for fantasy lineups, particularly against a Jacksonville defense vulnerable to passing attacks.

Michael Wilson has complemented Brissett’s resurgence by breaking out in Week 11, showcasing strong on-field chemistry with the quarterback. A key highlight includes a 25-yard gain on third down, illustrating Wilson’s ability to convert critical plays. His athleticism and recent target volume position him as a valuable FLEX option for fantasy rosters, benefiting from the Jaguars’ secondary, which struggles significantly against wide receivers.

Additionally, tight end Trey McBride offers notable upside due to his high target volume and the Jaguars’ documented difficulty in defending tight ends, especially in red-zone situations. However, Arizona’s running backs and defense are considered less appealing fantasy options this week and may only warrant consideration under strict salary constraints or specific roster needs.

This strategic focus on the Brissett-Wilson pairing aligns with a data-driven approach to fantasy football management, leveraging current player form and matchup analysis to maximize potential point outcomes. Given Jacksonville’s weakness in defending against quarterbacks and wide receivers, stacking these players provides a competitive edge for Daily Fantasy Sports lineups and season-long franchises seeking cost-effective, high-upside talent.

Fantasy managers looking to optimize their Week 12 lineups should consider the synergy and emerging consistency of the Cardinals’ passing game, centered on Brissett and Wilson, as a practical and informed acquisition—particularly in the final stages before game slates lock.